What happens when your vitamin B12 is low?
12 Complications of vitamin B12 or folate deficiency anaemia
Vitamin B12 plays a crucial role in many functions in the body, including the production of red blood cells, DNA synthesis, and proper functioning of the nervous system. When vitamin B12 levels are low, a range of symptoms and health problems can arise, including:
Here are 12 complications that can result from vitamin B12 or folate deficiency:
- Anemia: A deficiency in vitamin B12 or folate can cause a type of anemia called megaloblastic anemia, which results in the production of large, immature red blood cells.
- Neurological problems: Vitamin B12 deficiency can cause nerve damage, leading to tingling or numbness in the hands and feet, difficulty walking, memory problems, and depression.
- Fatigue: A lack of vitamin B12 or folate can cause fatigue and weakness.
- Cardiovascular disease: Low levels of vitamin B12 or folate have been linked to an increased risk of cardiovascular disease.
- Digestive problems: Vitamin B12 deficiency can cause digestive problems, such as constipation, diarrhea, and loss of appetite.
- Skin problems: A lack of vitamin B12 or folate can cause skin problems, such as pale skin, jaundice, and skin rashes.
- Cognitive decline: Low levels of vitamin B12 have been associated with cognitive decline and an increased risk of dementia.
- Birth defects: Folate deficiency during pregnancy can increase the risk of birth defects, such as neural tube defects.
- Osteoporosis: Vitamin B12 deficiency has been linked to an increased risk of osteoporosis, which can lead to fractures and bone loss.
- Increased risk of infections: Low levels of vitamin B12 or folate can weaken the immune system, increasing the risk of infections.
- Muscle weakness: A lack of vitamin B12 or folate can cause muscle weakness and reduced muscle function.
- Impaired vision: Vitamin B12 deficiency can cause optic neuropathy, a condition that affects the nerves that transmit visual information from the eyes to the brain, leading to impaired vision.
What are the main causes of vitamin B12 deficiency?

There are several causes of vitamin B12 deficiency, including:
- Inadequate dietary intake: Vitamin B12 is primarily found in animal products such as meat, fish, eggs, and dairy. Vegans and vegetarians who do not consume these foods may be at a higher risk of deficiency.
- Malabsorption: Some medical conditions can interfere with the absorption of vitamin B12 in the digestive tract. This includes conditions like pernicious anemia, celiac disease, Crohn’s disease, and certain types of gastrointestinal surgery.
- Medications: Certain medications, such as proton pump inhibitors (PPIs) and metformin, can interfere with vitamin B12 absorption.
- Aging: As people age, their bodies may become less efficient at absorbing vitamin B12 from food.
- Alcoholism: Chronic alcohol consumption can damage the lining of the stomach and intestines, leading to malabsorption of vitamin B12.
- Rare genetic conditions: There are rare genetic conditions that can affect the body’s ability to absorb or use vitamin B12.
9 Health Benefits of Vitamin B12

Vitamin B12 plays a crucial role in many bodily functions and provides several health benefits. Some of the health benefits of vitamin B12 include:
- Red blood cell formation: Vitamin B12 is essential for the production of red blood cells, which carry oxygen throughout the body.
- Nervous system health: Vitamin B12 is important for the proper functioning of the nervous system, and it helps maintain the health of the myelin sheath that surrounds and protects nerves.
- Brain function: Vitamin B12 plays a role in cognitive function and may help reduce the risk of cognitive decline and dementia in older adults.
- Energy metabolism: Vitamin B12 helps convert food into energy, and it is important for maintaining a healthy metabolism.
- Heart health: Vitamin B12 may help reduce the risk of heart disease by reducing levels of homocysteine, an amino acid that can contribute to heart disease.
- Mood regulation: Vitamin B12 may play a role in regulating mood and reducing the risk of depression and anxiety.
- Skin health: Vitamin B12 is important for the health of the skin and may help reduce the risk of certain skin conditions such as acne and eczema.
It is important to ensure that you are getting enough vitamin B12 in your diet or through supplements to reap these health benefits.
Do I need vitamin B12 supplement?
Here are some guidelines that can help you determine if you need a vitamin B12 supplement:
- Age: As you age, your body may become less efficient at absorbing vitamin B12 from food, so older adults may need to take a supplement to ensure they are getting enough.
- Diet: If you follow a vegan or vegetarian diet, you may be at higher risk of vitamin B12 deficiency because the vitamin is primarily found in animal products.
- Medical conditions: If you have a medical condition that affects the absorption of vitamin B12, such as pernicious anemia or Crohn’s disease, you may need a supplement.
- Medications: Certain medications, such as metformin and proton pump inhibitors (PPIs), can interfere with the absorption of vitamin B12 and may require supplementation.
What foods are rich in vitamin B12?

Vitamin B12 is found primarily in animal products, so the richest sources of vitamin B12 include:
- Clams: Clams are the richest source of vitamin B12, providing more than 1,000% of the daily value (DV) per 100-gram serving.
- Beef liver: Beef liver is a nutrient-dense food that is rich in vitamin B12, providing more than 1,000% of the DV per 100-gram serving.
- Salmon: Salmon is a good source of vitamin B12, providing about 80% of the DV per 100-gram serving.
- Trout: Trout is another type of fish that is a good source of vitamin B12, providing about 50% of the DV per 100-gram serving.
- Eggs: Eggs are a good source of vitamin B12, providing about 10% of the DV per large egg.
- Milk and dairy products: Milk, cheese, and yogurt are good sources of vitamin B12, providing about 20-30% of the DV per serving.
- Fortified foods: Some cereals, plant-based milks, and other products are fortified with vitamin B12 and can be a good source for vegans and vegetarians.
It’s important to note that vitamin B12 is not found naturally in plant foods, so vegans and vegetarians may need to supplement their diets or rely on fortified foods to get enough vitamin B12.